Proton beam therapy in patients with breast cancer: evaluating early and late effects
Disease Site: Breast cancer.
Treatment Modality: Proton beam therapy, radiotherapy
Status: Open to Recruitment
PARABLE is a phase III, multi-centre, randomised trial which aims to compare proton beam therapy (PBT) with tailored radiotherapy to assess whether PBT can reduce mean heart dose (a validated biomarker of longer term serious heart toxicity) without increasing shorter-term side effects, in patients with breast cancer who have increased risk of radiotherapy-induced heart toxicity.
192 patients will be recruited from UK sites over a 2.5 year period, with patients randomised to receive either PBT or tailored radiotherapy. PBT will be delivered either at The Christie NHS Foundation Trust or University College London NHS Foundation Trust. Patients will receive treatment for 3 weeks and will be followed up for a further 5 years.
Chief Investigator: Professor Charlotte Coles, University of Cambridge
ICR-CTSU Scientific Lead: Professor Judith Bliss
Technical RT and Mechanistic Lead: Dr Anna Kirby, The Royal Marsden
Methodology Lead: Jo Haviland, ICR-CTSU
Trial Management Contact: PARABLEemail@example.com
Sponsor: The Institute of Cancer Research
Funding: National Institute for Health Research (NIHR) – Efficacy and Mechanism Evaluation (EME) Programme (NIHR131120)
A lay summary in plain English is available from the National Institute for Health Research
NIHR Funding and Awards Search Website
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