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Light Microscopy Facility Chelsea
The Light Microscopy Facility in Chelsea is managed by Kai Betteridge and supported by Queenie Lai and Ross Scrimgeour.
It consists of 13 state-of-the-art microscopes for live and fixed cell analysis. The facility is composed of three parts:
1. Advanced light microscopy facility: two widefield microscopes for widefield imaging of samples and for long time lapse experiments of live cells, three confocal microscopes for different confocal imaging and for time-lapse experiments of live cells, three light sheet microscopes, one TIRF microscope for Total Internal Reflection of Fluorescence Microscopy.
2. High content screening facility: four plate based high-throughput microscopes.
3. State-of-the-art image analysis equipment and software: commercial software and dedicated image analysis computers (Celigo, MetaXpress, Aivia, Imaris, SlideBook, Harmony, Signals Image Artist, Velocity), open-source software (FIJI ImageJ, Cell Profiler and Cell Profiler Analyst, Python/Napari, Ilastik), other resources (including custom scripting eg MATLAB/Python, high-performance computing, ICR research data storage).
Light Microscopy Facility Sutton
The Light Microscopy Facility in Sutton is managed by Louise Howell. It consists of six advanced light microscopes geared towards state-of-the-art automated slide scanning and live cell confocal and fluorescence imaging.
The equipment includes two confocal microscopes for imaging fixed and live samples, and four slide scanners for brightfield and fluorescent slides.
There are also multiple dedicated image analysis computers with commercial software (eg Zeiss Axio Scan, Zeiss Zen software, Zeiss Zen Intellesis, Metacyte, In Situ Imaging System software, Tissue FISH module, V-slide software and VSViewer, Definiens Tissue Studio software, Hamamatsu NZ Acquire and NDP view 2, Duolink Image Tool), and open-source software (FIJI ImageJ, QuPath, Cell Profiler and Cell Profiler Analyst).