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Research Projects

Dr Rob van Montfort, Hit Discovery and Structural Design Team

Structure-based drug design of cancer drugs

  • Inhibitors of monopolar spindle 1 (MPS1) kinase
  • Inhibitors of the KDM4/5 JmJC histone demethylases
  • AGC kinase inhibitors

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Fragment-based lead discovery

  • Fragment screening of Checkpoint kinase 2
  • A fragment-based approach to target HSP70

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Assay development and screening

  • Identification of IRE1 inhibitors

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