Myles Smith completed his surgical training in Ireland, as a member of the Royal College of Surgeons in Ireland Higher Surgical Training scheme. After graduation, he joined the General Surgical Oncology Fellowship at the University of Toronto, before taking up a post at The Royal Marsden NHS Foundation Trust.
His postgraduate research degree with Professors TG Cotter (Biochemistry & Cell Biology, BioSciences Institute), and HP Redmond (Department of Surgery) in University College Cork, Ireland, investigated the effect of tumour heterogeneity of molecular profiles, and the mechanisms driving local recurrence after cancer surgery.
Smith's research subsequently has focused on molecular biomarkers in solid tumours, including incorporating new imaging techniques into the surgical cancer pathway.
In 2015, he took up a substantive post with the Sarcoma, Melanoma and Rare Tumours (SMART) service of The Royal Marsden, and joined The Institute of Cancer Research in 2017. He has developed specialist surgical oncology practice, with special interests in soft-tissue sarcoma and advanced melanoma. Smith has an interest in pelvic surgery and minimally invasive surgery, including robotics. He is also the Royal College Tutor at The Royal Marsden.