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Journal Articles

Csibi, A. Fendt, S.-. Li, C. Poulogiannis, G. Choo, A.Y. Chapski, D.J. Jeong, S.M. Dempsey, J.M. Parkhitko, A. Morrison, T. Henske, E.P. Haigis, M.C. Cantley, L.C. Stephanopoulos, G. Yu, J. Blenis, J. (2021). The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell, Vol.184 (8), pp. 2256-2256.

(2021). Correction for Emerling et al , Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proceedings of the national academy of sciences, Vol.118 (32).

Koundouros, N. Poulogiannis, G. (2020). Reprogramming of fatty acid metabolism in cancer. British journal of cancer, Vol.122 (1), pp. 4-22.  show abstract

Koundouros, N. Karali, E. Tripp, A. Valle, A. Inglese, P. Perry, N.J. Magee, D.J. Anjomani Virmouni, S. Elder, G.A. Tyson, A.L. Dória, M.L. van Weverwijk, A. Soares, R.F. Isacke, C.M. Nicholson, J.K. Glen, R.C. Takats, Z. Poulogiannis, G. (2020). Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids. Cell, Vol.181 (7), pp. 1596-1611.e27.  show abstract

Dannhorn, A. Kazanc, E. Ling, S. Nikula, C. Karali, E. Serra, M.P. Vorng, J.-. Inglese, P. Maglennon, G. Hamm, G. Swales, J. Strittmatter, N. Barry, S.T. Sansom, O.J. Poulogiannis, G. Bunch, J. Goodwin, R.J. Takats, Z. (2020). Universal Sample Preparation Unlocking Multimodal Molecular Tissue Imaging. Analytical chemistry, Vol.92 (16), pp. 11080-11088.

Magee, D.J. Jhanji, S. Poulogiannis, G. Farquhar-Smith, P. Brown, M.R. (2019). Nonsteroidal anti-inflammatory drugs and pain in cancer patients: a systematic review and reappraisal of the evidence. British journal of anaesthesia, Vol.123 (2), pp. e412-e423.

van Weverwijk, A. Koundouros, N. Iravani, M. Ashenden, M. Gao, Q. Poulogiannis, G. Jungwirth, U. Isacke, C.M. (2019). Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation. Nature communications, Vol.10 (1), pp. 2698-?.  show abstract

Turgeon, M.-. Perry, N.J. Poulogiannis, G. (2018). DNA Damage, Repair, and Cancer Metabolism. Frontiers in oncology, Vol.8, pp. 15-?.  show abstract

Koundouros, N. Poulogiannis, G. (2018). Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer. Frontiers in oncology, Vol.8, pp. 160-?.  show abstract

Hiller, J.G. Perry, N.J. Poulogiannis, G. Riedel, B. Sloan, E.K. (2018). Perioperative events influence cancer recurrence risk after surgery. Nature reviews. clinical oncology, Vol.15 (4), pp. 205-218.  show abstract

Knott, S.R. Wagenblast, E. Khan, S. Kim, S.Y. Soto, M. Wagner, M. Turgeon, M.-. Fish, L. Erard, N. Gable, A.L. Maceli, A.R. Dickopf, S. Papachristou, E.K. D'Santos, C.S. Carey, L.A. Wilkinson, J.E. Harrell, J.C. Perou, C.M. Goodarzi, H. Poulogiannis, G. Hannon, G.J. (2018). Asparagine bioavailability governs metastasis in a model of breast cancer. Nature, Vol.554 (7692), pp. 378-381.  show abstract

Gupta, A. Anjomani-Virmouni, S. Koundouros, N. Poulogiannis, G. (2017). PARK2 loss promotes cancer progression via redox-mediated inactivation of PTEN. Molecular & cellular oncology, Vol.4 (6), pp. e1329692-?.  show abstract

Gupta, A. Anjomani-Virmouni, S. Koundouros, N. Dimitriadi, M. Choo-Wing, R. Valle, A. Zheng, Y. Chiu, Y.-. Agnihotri, S. Zadeh, G. Asara, J.M. Anastasiou, D. Arends, M.J. Cantley, L.C. Poulogiannis, G. (2017). PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Molecular cell, Vol.65 (6), pp. 999-1013.e7.  show abstract

Martin, M. Dragoš, A. Hölscher, T. Maróti, G. Bálint, B. Westermann, M. Kovács, Á.T. (2017). De novo evolved interference competition promotes the spread of biofilm defectors. Nature communications, Vol.8 (1).

Martin, L.-. Ribas, R. Simigdala, N. Schuster, E. Pancholi, S. Tenev, T. Gellert, P. Buluwela, L. Harrod, A. Thornhill, A. Nikitorowicz-Buniak, J. Bhamra, A. Turgeon, M.-. Poulogiannis, G. Gao, Q. Martins, V. Hills, M. Garcia-Murillas, I. Fribbens, C. Patani, N. Li, Z. Sikora, M.J. Turner, N. Zwart, W. Oesterreich, S. Carroll, J. Ali, S. Dowsett, M. (2017). Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance. Nature communications, Vol.8 (1), pp. 1865-?.  show abstract

Poulogiannis, G. (2017). Deconstructing the Metabolic Networks of Oncogenic Signaling Using Targeted Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). , , pp. 405-414.

Mardakheh, F.K. Sailem, H.Z. Kümper, S. Tape, C.J. McCully, R.R. Paul, A. Anjomani-Virmouni, S. Jørgensen, C. Poulogiannis, G. Marshall, C.J. Bakal, C. (2016). Proteomics profiling of interactome dynamics by colocalisation analysis (COLA). Molecular biosystems, Vol.13 (1), pp. 92-105.  show abstract

Tape, C.J. Ling, S. Dimitriadi, M. McMahon, K.M. Worboys, J.D. Leong, H.S. Norrie, I.C. Miller, C.J. Poulogiannis, G. Lauffenburger, D.A. Jørgensen, C. (2016). Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation. Cell, Vol.165 (7), pp. 1818-1818.

Ip, L.R. Poulogiannis, G. Viciano, F.C. Sasaki, J. Kofuji, S. Spanswick, V.J. Hochhauser, D. Hartley, J.A. Sasaki, T. Gewinner, C.A. (2015). Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. Oncotarget, Vol.6 (12), pp. 10548-10562.  show abstract

Luo, F. Poulogiannis, G. Ye, H. Hamoudi, R. Dong, G. Zhang, W. Ibrahim, A.E. Arends, M.J. (2014). Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation. Int j exp pathol, Vol.95 (1), pp. 8-15.  show abstract

Day, E. Poulogiannis, G. McCaughan, F. Mulholland, S. Arends, M.J. Ibrahim, A.E. Dear, P.H. (2013). IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer. Int j exp pathol, Vol.94 (3), pp. 203-211.  show abstract

Emerling, B.M. Hurov, J.B. Poulogiannis, G. Tsukazawa, K.S. Choo-Wing, R. Wulf, G.M. Bell, E.L. Shim, H.-. Lamia, K.A. Rameh, L.E. Bellinger, G. Sasaki, A.T. Asara, J.M. Yuan, X. Bullock, A. Denicola, G.M. Song, J. Brown, V. Signoretti, S. Cantley, L.C. (2013). Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell, Vol.155 (4), pp. 844-857.  show abstract

Csibi, A. Fendt, S.-. Li, C. Poulogiannis, G. Choo, A.Y. Chapski, D.J. Jeong, S.M. Dempsey, J.M. Parkhitko, A. Morrison, T. Henske, E.P. Haigis, M.C. Cantley, L.C. Stephanopoulos, G. Yu, J. Blenis, J. (2013). The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell, Vol.153 (4), pp. 840-854.  show abstract

Kim, S.G. Hoffman, G.R. Poulogiannis, G. Buel, G.R. Jang, Y.J. Lee, K.W. Kim, B.-. Erikson, R.L. Cantley, L.C. Choo, A.Y. Blenis, J. (2013). Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. Mol cell, Vol.49 (1), pp. 172-185.  show abstract

Emerling, B.M. Benes, C.H. Poulogiannis, G. Bell, E.L. Courtney, K. Liu, H. Choo-Wing, R. Bellinger, G. Tsukazawa, K.S. Brown, V. Signoretti, S. Soltoff, S.P. Cantley, L.C. (2013). Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proc natl acad sci u s a, Vol.110 (9), pp. 3483-3488.  show abstract

van der Weyden, L. Papaspyropoulos, A. Poulogiannis, G. Rust, A.G. Rashid, M. Adams, D.J. Arends, M.J. O'Neill, E. (2012). Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis. Cancer res, Vol.72 (15), pp. 3817-3827.  show abstract

Poulogiannis, G. Luo, F. Arends, M.J. (2012). RAS signalling in the colorectum in health and disease. Cell commun adhes, Vol.19 (1), pp. 1-9.  show abstract

Benes, C.H. Poulogiannis, G. Cantley, L.C. Soltoff, S.P. (2012). The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility. Oncogene, Vol.31 (5), pp. 653-663.  show abstract

van der Weyden, L. Arends, M.J. Rust, A.G. Poulogiannis, G. McIntyre, R.E. Adams, D.J. (2012). Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1. Mol cancer, Vol.11, p. 29.  show abstract

Wilson, C.H. Crombie, C. van der Weyden, L. Poulogiannis, G. Rust, A.G. Pardo, M. Gracia, T. Yu, L. Choudhary, J. Poulin, G.B. McIntyre, R.E. Winton, D.J. March, H.N. Arends, M.J. Fraser, A.G. Adams, D.J. (2012). Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. Embo j, Vol.31 (11), pp. 2486-2497.  show abstract

Anastasiou, D. Poulogiannis, G. Asara, J.M. Boxer, M.B. Jiang, J.-. Shen, M. Bellinger, G. Sasaki, A.T. Locasale, J.W. Auld, D.S. Thomas, C.J. Vander Heiden, M.G. Cantley, L.C. (2011). Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science, Vol.334 (6060), pp. 1278-1283.  show abstract

Luo, F. Poulogiannis, G. Ye, H. Hamoudi, R. Zhang, W. Dong, G. Arends, M.J. (2011). Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability. J pathol, Vol.223 (3), pp. 390-399.  show abstract

Luo, F. Poulogiannis, G. Ye, H. Hamoudi, R. Arends, M.J. (2011). Synergism between K-rasVal12 and mutant Apc accelerates murine large intestinal tumourigenesis. Oncol rep, Vol.26 (1), pp. 125-133.  show abstract

Yu, Y. Yoon, S.-. Poulogiannis, G. Yang, Q. Ma, X.M. Villén, J. Kubica, N. Hoffman, G.R. Cantley, L.C. Gygi, S.P. Blenis, J. (2011). Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science, Vol.332 (6035), pp. 1322-1326.  show abstract

Poulogiannis, G. Frayling, I.M. Arends, M.J. (2010). DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndrome. Histopathology, Vol.56 (2), pp. 167-179.  show abstract

Poulogiannis, G. Ichimura, K. Hamoudi, R.A. Luo, F. Leung, S.Y. Yuen, S.T. Harrison, D.J. Wyllie, A.H. Arends, M.J. (2010). Prognostic relevance of DNA copy number changes in colorectal cancer. J pathol, Vol.220 (3), pp. 338-347.  show abstract

Luo, F. Ye, H. Hamoudi, R. Dong, G. Zhang, W. Patek, C.E. Poulogiannis, G. Arends, M.J. (2010). K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation. J pathol, Vol.220 (5), pp. 542-550.  show abstract

Lee, S.H. Poulogiannis, G. Pyne, S. Jia, S. Zou, L. Signoretti, S. Loda, M. Cantley, L.C. Roberts, T.M. (2010). A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice. Proc natl acad sci u s a, Vol.107 (24), pp. 11002-11007.  show abstract

Poulogiannis, G. McIntyre, R.E. Dimitriadi, M. Apps, J.R. Wilson, C.H. Ichimura, K. Luo, F. Cantley, L.C. Wyllie, A.H. Adams, D.J. Arends, M.J. (2010). PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice. Proc natl acad sci u s a, Vol.107 (34), pp. 15145-15150.  show abstract

Luo, F. Brooks, D.G. Ye, H. Hamoudi, R. Poulogiannis, G. Patek, C.E. Winton, D.J. Arends, M.J. (2009). Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways. Int j exp pathol, Vol.90 (5), pp. 558-574.  show abstract

Dimitriadi, M. Poulogiannis, G. Liu, L. Bäcklund, L.M. Pearson, D.M. Ichimura, K. Collins, V.P. (2008). p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours. Br j cancer, Vol.99 (7), pp. 1144-1152.  show abstract

Luo, F. Brooks, D.G. Ye, H. Hamoudi, R. Poulogiannis, G. Patek, C.E. Winton, D.J. Arends, M.J. (2007). Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice. Oncogene, Vol.26 (30), pp. 4415-4427.  show abstract

Dimitriadi, M. Derdowski, A. Kalloo, G. Maginnis, M.S. O'Hern, P. Bliska, B. Sorkaç, A. Nguyen, K.C. Cook, S.J. Poulogiannis, G. Atwood, W.J. Hall, D.H. Hart, A.C. Decreased function of survival motor neuron protein impairs endocytic pathways. Proc natl acad sci u s a, Vol.113 (30), pp. E4377-E4386.  show abstract


Conferences

Emerling, B.M.Hurov, J.B.Poulogiannis, G.Choo-Wing, R.Wulf, G.M.Shim, H.-.Lamia, K.A.Rameh, L.E.Yuan, X.Bullock, A.DeNicola, G.M.Song, J.Signoretti, S.Cantley, L.C. (2014). Abstract NG05: Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53 null tumors, Cancer Research, Vol.74 (19_Supplement), p.NG05.

Emerling, B.M.Benes, C.Bell, E.Poulogiannis, G.Courtney, K.Lui, H.Choo-Wing, R.Bellinger, G.Soltoff, S.Cantley, L. (2013). Abstract 4588: Identification of CDCP1 as a HIF-2α target gene involved in the regulation of cancer cell migration and metastasis., Cancer Research, Vol.73 (8_Supplement), p.4588.

Luo, F.Poulogiannis, G.Ye, H.Hamoudi, R.Ibrahim, A.E.Arends, M.J. (2012). Wild-type K-ras Exerts a Tumour Suppressor Effect on Carcinogen-Induced Colorectal Adenomagenesis in the Mouse, JOURNAL OF PATHOLOGY, Vol.228, p.S21.

Poulogiannis, G.McIntyre, R.E.Dimitriadi, M.Apps, J.R.Wilson, C.H.Wyllie, A.H.Adams, D.J.Arends, M.J. (2011). Deletion of PARK2 Frequently Occurs in Colorectal Cancer and Promotes Adenoma Development in Apc Mutant Mice, JOURNAL OF PATHOLOGY, Vol.224, p.S4.

Arends, M.J.Wilson, C.H.Poulin, G.B.Crombie, C.Rust, A.G.March, N.H.Poulogiannis, G.Fraser, A.G.Adams, D.J. (2011). Screening for Genes that Cooperate with Mutant RAS Identified NRBP1 as a Novel Tumour Suppressor that Regulates the WNT Pathway, JOURNAL OF PATHOLOGY, Vol.224, p.S18.

Poulogiannis, G.Ichimura, K.Apps, J.R.Luo, F.Frayling, I.M.Morris, R.G.Harrison, D.J.Collins, V.P.Ibrahim, A.Wyllie, A.H.Arends, M.J. (2006). Small-scale genomic abnormalities on specific chromosomes in sporadic colorectal cancers are associated with poorer survival., JOURNAL OF PATHOLOGY, Vol.208, p.14A.

Poulogiannis, G.Ichimura, K.Miller, N.G.Frayling, I.M.Morris, R.G.Harrison, D.J.Collins, V.P.Ibrahim, A.Wyllie, A.H.Arends, M.J. (2006). Cyclin D2 gene abnormalities in colorectal cancers identified by array comparative genomic hybridisation, JOURNAL OF PATHOLOGY, Vol.210, p.13.

Watkins, A.J.Poulogiannis, G.Daly, K.Johnson, N.Du, M.-.Ibrahim, A.E.Wyllie, A.H.Arends, M.J. (2006). Array comparative genomic hybridization profiling of early invasion in colorectal adenomas, JOURNAL OF PATHOLOGY, Vol.210, p.1.

Poulogiannis, G.Ichimura, K.Miller, N.G.Frayling, I.M.Morris, R.G.Harrison, D.J.Collins, V.P.Ibrahim, A.Wyllie, A.H. (2005). 1Mb resolution array-CGH identifies small chromosome aberrations in chromosome unstable and microsatellite unstable colorectal cancers, JOURNAL OF PATHOLOGY, Vol.205, p.1.

Poulogiannis, G.Ichimura, K.Miller, N.G.Frayling, I.M.Morris, R.G.Harrison, D.J.Collins, V.P.Ibrahim, A.E.Wyllie, A.H.Arends, M.J. (2005). 1Mb resolution array-CGH identifies small chromosome aberrations in colorectal cancers, JOURNAL OF PATHOLOGY, Vol.207, p.47.

Poulogiannis, G.Ichimura, K.Miller, N.G.Frayling, I.M.Morris, R.G.Harrison, D.J.Collins, V.P.Ibrahim, A.Wyllie, A.H.Arends, M.J. (2004). Array-CGH demonstrates chromosome aberrations in both near-diploid and microsatellite unstable colorectal cancers, JOURNAL OF PATHOLOGY, Vol.204, p.4A.