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Pierrat, O.A. Liu, M. Collie, G.W. Shetty, K. Rodrigues, M.J. Le Bihan, Y.-. Gunnell, E.A. McAndrew, P.C. Stubbs, M. Rowlands, M.G. Yahya, N. Shehu, E. Talbot, R. Pickard, L. Bellenie, B.R. Cheung, K.-. Drouin, L. Innocenti, P. Woodward, H. Davis, O.A. Lloyd, M.G. Varela, A. Huckvale, R. Broccatelli, F. Carter, M. Galiwango, D. Hayes, A. Raynaud, F.I. Bryant, C. Whittaker, S. Rossanese, O.W. Hoelder, S. Burke, R. van Montfort, R.L. (2022). Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays. , Vol.12 (1), p. 18633.  show abstract

Davis, O.A. Cheung, K.-. Brennan, A. Lloyd, M.G. Rodrigues, M.J. Pierrat, O.A. Collie, G.W. Le Bihan, Y.-. Huckvale, R. Harnden, A.C. Varela, A. Bright, M.D. Eve, P. Hayes, A. Henley, A.T. Carter, M.D. McAndrew, P.C. Talbot, R. Burke, R. van Montfort, R.L. Raynaud, F.I. Rossanese, O.W. Meniconi, M. Bellenie, B.R. Hoelder, S. (2022). Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors. , Vol.65 (12), pp. 8169-8190.  show abstract

Huckvale, R. Harnden, A.C. Cheung, K.-. Pierrat, O.A. Talbot, R. Box, G.M. Henley, A.T. de Haven Brandon, A.K. Hallsworth, A.E. Bright, M.D. Akpinar, H.A. Miller, D.S. Tarantino, D. Gowan, S. Hayes, A. Gunnell, E.A. Brennan, A. Davis, O.A. Johnson, L.D. de Klerk, S. McAndrew, C. Le Bihan, Y.-. Meniconi, M. Burke, R. Kirkin, V. van Montfort, R.L. Raynaud, F.I. Rossanese, O.W. Bellenie, B.R. Hoelder, S. (2022). Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo. , Vol.65 (12), pp. 8191-8207.  show abstract

Davidson, K. Grevitt, P. Contreras-Gerenas, M.F. Bridge, K.S. Hermida, M. Shah, K.M. Mardakheh, F.K. Stubbs, M. Burke, R. Casado, P. Cutillas, P.R. Martin, S.A. Sharp, T.V. (2021). Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes. Cell death & disease, Vol.12 (11), pp. 1075-?.  show abstract

Bellenie, B.R. Cheung, K.-. Varela, A. Pierrat, O.A. Collie, G.W. Box, G.M. Bright, M.D. Gowan, S. Hayes, A. Rodrigues, M.J. Shetty, K.N. Carter, M. Davis, O.A. Henley, A.T. Innocenti, P. Johnson, L.D. Liu, M. de Klerk, S. Le Bihan, Y.-. Lloyd, M.G. McAndrew, P.C. Shehu, E. Talbot, R. Woodward, H.L. Burke, R. Kirkin, V. van Montfort, R.L. Raynaud, F.I. Rossanese, O.W. Hoelder, S. (2020). Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders. Journal of medicinal chemistry, Vol.63 (8), pp. 4047-4068.  show abstract

Acar, A. Nichol, D. Fernandez-Mateos, J. Cresswell, G.D. Barozzi, I. Hong, S.P. Trahearn, N. Spiteri, I. Stubbs, M. Burke, R. Stewart, A. Caravagna, G. Werner, B. Vlachogiannis, G. Maley, C.C. Magnani, L. Valeri, N. Banerji, U. Sottoriva, A. (2020). Exploiting evolutionary steering to induce collateral drug sensitivity in cancer. Nature communications, Vol.11 (1), pp. 1923-?.  show abstract

Colombano, G. Caldwell, J.J. Matthews, T.P. Bhatia, C. Joshi, A. McHardy, T. Mok, N.Y. Newbatt, Y. Pickard, L. Strover, J. Hedayat, S. Walton, M.I. Myers, S.M. Jones, A.M. Saville, H. McAndrew, C. Burke, R. Eccles, S.A. Davies, F.E. Bayliss, R. Collins, I. (2019). Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease. Journal of medicinal chemistry, Vol.62 (5), pp. 2447-2465.  show abstract

Clarke, P.A. Roe, T. Swabey, K. Hobbs, S.M. McAndrew, C. Tomlin, K. Westwood, I. Burke, R. van Montfort, R. Workman, P. (2019). Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer. Oncogene, Vol.38 (25), pp. 5076-5090.  show abstract

Le Bihan, Y.-. Lanigan, R.M. Atrash, B. McLaughlin, M.G. Velupillai, S. Malcolm, A.G. England, K.S. Ruda, G.F. Mok, N.Y. Tumber, A. Tomlin, K. Saville, H. Shehu, E. McAndrew, C. Carmichael, L. Bennett, J.M. Jeganathan, F. Eve, P. Donovan, A. Hayes, A. Wood, F. Raynaud, F.I. Fedorov, O. Brennan, P.E. Burke, R. van Montfort, R.L. Rossanese, O.W. Blagg, J. Bavetsias, V. (2019). C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. European journal of medicinal chemistry, Vol.177, pp. 316-337.  show abstract

Anderhub, S.J. Mak, G.W. Gurden, M.D. Faisal, A. Drosopoulos, K. Walsh, K. Woodward, H.L. Innocenti, P. Westwood, I.M. Naud, S. Hayes, A. Theofani, E. Filosto, S. Saville, H. Burke, R. van Montfort, R.L. Raynaud, F.I. Blagg, J. Hoelder, S. Eccles, S.A. Linardopoulos, S. (2019). High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers. Molecular cancer therapeutics, Vol.18 (10), pp. 1696-1707.  show abstract

Felisberto-Rodrigues, C. Thomas, J.C. McAndrew, C. Le Bihan, Y.-. Burke, R. Workman, P. van Montfort, R.L. (2019). Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release. The biochemical journal, Vol.476 (18), pp. 2521-2543.  show abstract

Chessum, N.E. Sharp, S.Y. Caldwell, J.J. Pasqua, A.E. Wilding, B. Colombano, G. Collins, I. Ozer, B. Richards, M. Rowlands, M. Stubbs, M. Burke, R. McAndrew, P.C. Clarke, P.A. Workman, P. Cheeseman, M.D. Jones, K. (2018). Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766). Journal of medicinal chemistry, Vol.61 (3), pp. 918-933.  show abstract

Vlachogiannis, G. Hedayat, S. Vatsiou, A. Jamin, Y. Fernández-Mateos, J. Khan, K. Lampis, A. Eason, K. Huntingford, I. Burke, R. Rata, M. Koh, D.-. Tunariu, N. Collins, D. Hulkki-Wilson, S. Ragulan, C. Spiteri, I. Moorcraft, S.Y. Chau, I. Rao, S. Watkins, D. Fotiadis, N. Bali, M. Darvish-Damavandi, M. Lote, H. Eltahir, Z. Smyth, E.C. Begum, R. Clarke, P.A. Hahne, J.C. Dowsett, M. de Bono, J. Workman, P. Sadanandam, A. Fassan, M. Sansom, O.J. Eccles, S. Starling, N. Braconi, C. Sottoriva, A. Robinson, S.P. Cunningham, D. Valeri, N. (2018). Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science (new york, n.y.), Vol.359 (6378), pp. 920-926.  show abstract

Lampis, A. Carotenuto, P. Vlachogiannis, G. Cascione, L. Hedayat, S. Burke, R. Clarke, P. Bosma, E. Simbolo, M. Scarpa, A. Yu, S. Cole, R. Smyth, E. Mateos, J.F. Begum, R. Hezelova, B. Eltahir, Z. Wotherspoon, A. Fotiadis, N. Bali, M.A. Nepal, C. Khan, K. Stubbs, M. Hahne, J.C. Gasparini, P. Guzzardo, V. Croce, C.M. Eccles, S. Fassan, M. Cunningham, D. Andersen, J.B. Workman, P. Valeri, N. Braconi, C. (2018). MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma. Gastroenterology, Vol.154 (4), pp. 1066-1079.e5.  show abstract

Liu, M. Mallinger, A. Tortorici, M. Newbatt, Y. Richards, M. Mirza, A. van Montfort, R.L. Burke, R. Blagg, J. Kaserer, T. (2018). Evaluation of APOBEC3B Recognition Motifs by NMR Reveals Preferred Substrates. Acs chemical biology, Vol.13 (9), pp. 2427-2432.  show abstract

Meyers, J. Chessum, N.E. Ali, S. Mok, N.Y. Wilding, B. Pasqua, A.E. Rowlands, M. Tucker, M.J. Evans, L.E. Rye, C.S. O'Fee, L. Le Bihan, Y.-. Burke, R. Carter, M. Workman, P. Blagg, J. Brown, N. van Montfort, R.L. Jones, K. Cheeseman, M.D. (2018). Privileged Structures and Polypharmacology within and between Protein Families. Acs medicinal chemistry letters, Vol.9 (12), pp. 1199-1204.  show abstract

Woodward, H.L. Innocenti, P. Cheung, K.-. Hayes, A. Roberts, J. Henley, A.T. Faisal, A. Mak, G.W. Box, G. Westwood, I.M. Cronin, N. Carter, M. Valenti, M. De Haven Brandon, A. O'Fee, L. Saville, H. Schmitt, J. Burke, R. Broccatelli, F. van Montfort, R.L. Raynaud, F.I. Eccles, S.A. Linardopoulos, S. Blagg, J. Hoelder, S. (2018). Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N8-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722). J med chem, Vol.61 (18), pp. 8226-8240.  show abstract

Cheeseman, M.D. Chessum, N.E. Rye, C.S. Pasqua, A.E. Tucker, M.J. Wilding, B. Evans, L.E. Lepri, S. Richards, M. Sharp, S.Y. Ali, S. Rowlands, M. O'Fee, L. Miah, A. Hayes, A. Henley, A.T. Powers, M. Te Poele, R. De Billy, E. Pellegrino, L. Raynaud, F. Burke, R. van Montfort, R.L. Eccles, S.A. Workman, P. Jones, K. (2017). Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. Journal of medicinal chemistry, Vol.60 (1), pp. 180-201.  show abstract

Hatch, S.B. Yapp, C. Montenegro, R.C. Savitsky, P. Gamble, V. Tumber, A. Ruda, G.F. Bavetsias, V. Fedorov, O. Atrash, B. Raynaud, F. Lanigan, R. Carmichael, L. Tomlin, K. Burke, R. Westaway, S.M. Brown, J.A. Prinjha, R.K. Martinez, E.D. Oppermann, U. Schofield, C.J. Bountra, C. Kawamura, A. Blagg, J. Brennan, P.E. Rossanese, O. Müller, S. (2017). Assessing histone demethylase inhibitors in cells: lessons learned. Epigenetics & chromatin, Vol.10, pp. 9-?.  show abstract

Faisal, A. Mak, G.W. Gurden, M.D. Xavier, C.P. Anderhub, S.J. Innocenti, P. Westwood, I.M. Naud, S. Hayes, A. Box, G. Valenti, M.R. De Haven Brandon, A.K. O'Fee, L. Schmitt, J. Woodward, H.L. Burke, R. vanMontfort, R.L. Blagg, J. Raynaud, F.I. Eccles, S.A. Hoelder, S. Linardopoulos, S. (2017). Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy. British journal of cancer, Vol.116 (9), pp. 1166-1176.  show abstract

Bavetsias, V. Lanigan, R.M. Ruda, G.F. Atrash, B. McLaughlin, M.G. Tumber, A. Mok, N.Y. Le Bihan, Y.-. Dempster, S. Boxall, K.J. Jeganathan, F. Hatch, S.B. Savitsky, P. Velupillai, S. Krojer, T. England, K.S. Sejberg, J. Thai, C. Donovan, A. Pal, A. Scozzafava, G. Bennett, J.M. Kawamura, A. Johansson, C. Szykowska, A. Gileadi, C. Burgess-Brown, N.A. von Delft, F. Oppermann, U. Walters, Z. Shipley, J. Raynaud, F.I. Westaway, S.M. Prinjha, R.K. Fedorov, O. Burke, R. Schofield, C.J. Westwood, I.M. Bountra, C. Müller, S. van Montfort, R.L. Brennan, P.E. Blagg, J. (2016). 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. Journal of medicinal chemistry, Vol.59 (4), pp. 1388-1409.  show abstract

Mallinger, A. Schiemann, K. Rink, C. Stieber, F. Calderini, M. Crumpler, S. Stubbs, M. Adeniji-Popoola, O. Poeschke, O. Busch, M. Czodrowski, P. Musil, D. Schwarz, D. Ortiz-Ruiz, M.-. Schneider, R. Thai, C. Valenti, M. de Haven Brandon, A. Burke, R. Workman, P. Dale, T. Wienke, D. Clarke, P.A. Esdar, C. Raynaud, F.I. Eccles, S.A. Rohdich, F. Blagg, J. (2016). Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19. Journal of medicinal chemistry, Vol.59 (3), pp. 1078-1101.  show abstract

Mallinger, A. Schiemann, K. Rink, C. Sejberg, J. Honey, M.A. Czodrowski, P. Stubbs, M. Poeschke, O. Busch, M. Schneider, R. Schwarz, D. Musil, D. Burke, R. Urbahns, K. Workman, P. Wienke, D. Clarke, P.A. Raynaud, F.I. Eccles, S.A. Esdar, C. Rohdich, F. Blagg, J. (2016). 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19. Acs medicinal chemistry letters, Vol.7 (6), pp. 573-578.  show abstract

Jones, A.M. Westwood, I.M. Osborne, J.D. Matthews, T.P. Cheeseman, M.D. Rowlands, M.G. Jeganathan, F. Burke, R. Lee, D. Kadi, N. Liu, M. Richards, M. McAndrew, C. Yahya, N. Dobson, S.E. Jones, K. Workman, P. Collins, I. van Montfort, R.L. (2016). A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Scientific reports, Vol.6, pp. 34701-?.  show abstract

Innocenti, P. Woodward, H.L. Solanki, S. Naud, S. Westwood, I.M. Cronin, N. Hayes, A. Roberts, J. Henley, A.T. Baker, R. Faisal, A. Mak, G.W. Box, G. Valenti, M. De Haven Brandon, A. O'Fee, L. Saville, H. Schmitt, J. Matijssen, B. Burke, R. van Montfort, R.L. Raynaud, F.I. Eccles, S.A. Linardopoulos, S. Blagg, J. Hoelder, S. (2016). Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach. Journal of medicinal chemistry, Vol.59 (8), pp. 3671-3688.  show abstract

Vaughan, L. Clarke, P.A. Barker, K. Chanthery, Y. Gustafson, C.W. Tucker, E. Renshaw, J. Raynaud, F. Li, X. Burke, R. Jamin, Y. Robinson, S.P. Pearson, A. Maira, M. Weiss, W.A. Workman, P. Chesler, L. (2016). Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors. Oncotarget, Vol.7 (36), pp. 57525-57544.  show abstract

Cheeseman, M.D. Westwood, I.M. Barbeau, O. Rowlands, M. Dobson, S. Jones, A.M. Jeganathan, F. Burke, R. Kadi, N. Workman, P. Collins, I. van Montfort, R.L. Jones, K. (2016). Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70. Journal of medicinal chemistry, Vol.59 (10), pp. 4625-4636.  show abstract

Rodgers, U.R. Lanyon-Hogg, T. Masumoto, N. Ritzefeld, M. Burke, R. Blagg, J. Magee, A.I. Tate, E.W. (2016). Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells. Acs chemical biology, Vol.11 (12), pp. 3256-3262.  show abstract

Tisi, D. Chiarparin, E. Tamanini, E. Pathuri, P. Coyle, J.E. Hold, A. Holding, F.P. Amin, N. Martin, A.C. Rich, S.J. Berdini, V. Yon, J. Acklam, P. Burke, R. Drouin, L. Harmer, J.E. Jeganathan, F. van Montfort, R.L. Newbatt, Y. Tortorici, M. Westlake, M. Wood, A. Hoelder, S. Heightman, T.D. (2016). Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives. Acs chemical biology, Vol.11 (11), pp. 3093-3105.

Joshi, A. Newbatt, Y. McAndrew, P.C. Stubbs, M. Burke, R. Richards, M.W. Bhatia, C. Caldwell, J.J. McHardy, T. Collins, I. Bayliss, R. (2015). Molecular mechanisms of human IRE1 activation through dimerization and ligand binding. Oncotarget, Vol.6 (15), pp. 13019-13035.  show abstract

Bavetsias, V. Pérez-Fuertes, Y. McIntyre, P.J. Atrash, B. Kosmopoulou, M. O’Fee, L. Burke, R. Sun, C. Faisal, A. Bush, K. Avery, S. Henley, A. Raynaud, F.I. Linardopoulos, S. Bayliss, R. Blagg, J. (2015). 7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent. Bioorganic & medicinal chemistry letters, Vol.25 (19), pp. 4203-4209.

Gurden, M.D. Westwood, I.M. Faisal, A. Naud, S. Cheung, K.-. McAndrew, C. Wood, A. Schmitt, J. Boxall, K. Mak, G. Workman, P. Burke, R. Hoelder, S. Blagg, J. Van Montfort, R.L. Linardopoulos, S. (2015). Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer research, Vol.75 (16), pp. 3340-3354.  show abstract

Cheeseman, M.D. Faisal, A. Rayter, S. Barbeau, O.R. Kalusa, A. Westlake, M. Burke, R. Swan, M. van Montfort, R. Linardopoulos, S. Jones, K. (2014). Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines. Bioorg med chem lett, Vol.24 (15), pp. 3469-3474.  show abstract

Stowell, A. Hamilton, N. Hitchin, J. Blagg, J. Burke, R. Burns, S. Cockerill, M.J. Fairweather, E. Hutton, C. Jordan, A. Mould, D. Thomson, G. Waddell, I. Ogilvie, D. (2013). Abstract B98: Development and evaluation of selective, reversible LSD1 inhibitors from fragment startpoints. Molecular cancer therapeutics, Vol.12 (11_Supplement), pp. B98-B98.  show abstract

Newbatt, Y. Hardcastle, A. McAndrew, P.C. Strover, J.A. Mirza, A. Morgan, G.J. Burke, R. Davies, F.E. Collins, I. van Montfort, R.L. (2013). Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay. J biomol screen, Vol.18 (3), pp. 298-308.  show abstract

Hitchin, J.R. Blagg, J. Burke, R. Burns, S. Cockerill, M.J. Fairweather, E.E. Hutton, C. Jordan, A.M. McAndrew, C. Mirza, A. Mould, D. Thomson, G.J. Waddell, I. Ogilvie, D.J. (2013). Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments. Medchemcomm, Vol.4 (11), pp. 1513-1522.

Bavetsias, V. Faisal, A. Crumpler, S. Brown, N. Kosmopoulou, M. Joshi, A. Atrash, B. Pérez-Fuertes, Y. Schmitt, J.A. Boxall, K.J. Burke, R. Sun, C. Avery, S. Bush, K. Henley, A. Raynaud, F.I. Workman, P. Bayliss, R. Linardopoulos, S. Blagg, J. (2013). Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells. J med chem, Vol.56 (22), pp. 9122-9135.  show abstract

Silva-Santisteban, M.C. Westwood, I.M. Boxall, K. Brown, N. Peacock, S. McAndrew, C. Barrie, E. Richards, M. Mirza, A. Oliver, A.W. Burke, R. Hoelder, S. Jones, K. Aherne, G.W. Blagg, J. Collins, I. Garrett, M.D. van Montfort, R.L. (2013). Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2. Plos one, Vol.8 (6), p. e65689.  show abstract

Naud, S. Westwood, I.M. Faisal, A. Sheldrake, P. Bavetsias, V. Atrash, B. Cheung, K.M. Liu, M. Hayes, A. Schmitt, J. Wood, A. Choi, V. Boxall, K. Mak, G. Gurden, M. Valenti, M. de Haven Brandon, A. Henley, A. Baker, R. McAndrew, C. Matijssen, B. Burke, R. Hoelder, S. Eccles, S.A. Raynaud, F.I. Linardopoulos, S. Van Montfort, R.L. Blagg, J. (2013). Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of the mitotic kinase monopolar spindle 1 (MPS1). J med chem, Vol.56, pp. 10045-10065.

Faisal, A. Naud, S. Schmitt, J. Westwood, I. Hayes, A. Gurden, M. Bavetsias, V. Berry, T. Mak, G. Innocenti, P. Cheung, J. Sheldrake, P. Atrash, B. Sun, C. Matijssen, B. Burke, R. Baker, R. McAndrew, C. Rowlands, M. Workman, P. Eccles, S.A. Hoelder, S. Raynaud, F.I. vanMontfort, R. Blagg, J. Linardopoulos, S. (2012). Abstract 1817: Characterisation of CCT251455, a novel, selective and highly potent Mps1 kinase inhibitor. Cancer research, Vol.72 (8_Supplement), pp. 1817-1817.  show abstract

Sime, M. Allan, A.C. Chapman, P. Fieldhouse, C. Giblin, G.M. Healy, M.P. Lambert, M.H. Leesnitzer, L.M. Lewis, A. Merrihew, R.V. Rutter, R.A. Sasse, R. Shearer, B.G. Willson, T.M. Xu, R.X. Virley, D.J. (2011). Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARγ partial agonist. Bioorg med chem lett, Vol.21 (18), pp. 5568-5572.  show abstract

Rimland, J. Dunne, A. Hunjan, S. Sasse, R. Uings, I. Montanari, D. Caivano, M. Shah, P. Standing, D. Gray, D. Brown, D. Cairns, W. Trump, R. Smith, P.W. Bertheleme, N. D'Alessandro, P. Gul, S. Vimal, M. Smith, D.W. Watson, S.P. (2010). The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist. Bioorg med chem lett, Vol.20 (7), pp. 2340-2343.  show abstract

Hall, A. Elliott, R.L. Giblin, G.M. Hussain, I. Musgrave, J. Naylor, A. Sasse, R. Smith, B. (2010). Piperidine-derived gamma-secretase modulators. Bioorg med chem lett, Vol.20 (3), pp. 1306-1311.  show abstract

Yates, C.M. Brown, P.J. Stewart, E.L. Patten, C. Austin, R.J. Holt, J.A. Maglich, J.M. Angell, D.C. Sasse, R.Z. Taylor, S.J. Uings, I.J. Trump, R.P. (2010). Structure guided design of 5-arylindazole glucocorticoid receptor agonists and antagonists. J med chem, Vol.53 (11), pp. 4531-4544.  show abstract

Barnett, H.A. Coe, D.M. Cooper, T.W. Jack, T.I. Jones, H.T. Macdonald, S.J. McLay, I.M. Rayner, N. Sasse, R.Z. Shipley, T.J. Skone, P.A. Somers, G.I. Taylor, S. Uings, I.J. Woolven, J.M. Weingarten, G.G. (2009). Aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists. Bioorg med chem lett, Vol.19 (1), pp. 158-162.  show abstract

Procopiou, P.A. Barrett, V.J. Bevan, N.J. Biggadike, K. Butchers, P.R. Coe, D.M. Conroy, R. Edney, D.D. Field, R.N. Ford, A.J. Guntrip, S.B. Looker, B.E. McLay, I.M. Monteith, M.J. Morrison, V.S. Mutch, P.J. Richards, S.A. Sasse, R. Smith, C.E. (2009). Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating arylsulfonamide groups. J med chem, Vol.52 (8), pp. 2280-2288.  show abstract


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