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Journal Articles

Schiavoni, F. Zuazua-Villar, P. Roumeliotis, T.I. Benstead-Hume, G. Pardo, M. Pearl, F.M. Choudhary, J.S. Downs, J.A. (2022). Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness. , Vol.13 (1), p. 1731.  show abstract

Feng, H. Lane, K.A. Roumeliotis, T.I. Jeggo, P.A. Somaiah, N. Choudhary, J.S. Downs, J.A. (2022). PBAF loss leads to DNA damage-induced inflammatory signaling through defective G2/M checkpoint maintenance. , .  show abstract

Chabanon, R.M. Morel, D. Eychenne, T. Colmet-Daage, L. Bajrami, I. Dorvault, N. Garrido, M. Meisenberg, C. Lamb, A. Ngo, C. Hopkins, S.R. Roumeliotis, T.I. Jouny, S. Hénon, C. Kawai-Kawachi, A. Astier, C. Konde, A. Del Nery, E. Massard, C. Pettitt, S.J. Margueron, R. Choudhary, J.S. Almouzni, G. Soria, J.-. Deutsch, E. Downs, J.A. Lord, C.J. Postel-Vinay, S. (2021). PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer. , Vol.81 (11), pp. 2888-2902.  show abstract

Lindenburg, L.H. Pantelejevs, T. Gielen, F. Zuazua-Villar, P. Butz, M. Rees, E. Kaminski, C.F. Downs, J.A. Hyvönen, M. Hollfelder, F. (2021). Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats. , Vol.118 (46), p. e2017708118.  show abstract

Flaus, A. Downs, J.A. Owen-Hughes, T. (2020). Histone isoforms and the oncohistone code. Current opinion in genetics & development, Vol.67, pp. 61-66.  show abstract

Harrod, A. Lane, K.A. Downs, J.A. (2020). The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks. Dna repair (amst), Vol.93, pp. 102919-102919.  show abstract

Rother, M.B. Pellegrino, S. Smith, R. Gatti, M. Meisenberg, C. Wiegant, W.W. Luijsterburg, M.S. Imhof, R. Downs, J.A. Vertegaal, A.C. Huet, S. Altmeyer, M. van Attikum, H. (2020). CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks. Nature communications, Vol.11 (1), pp. 5775-?.  show abstract

Meisenberg, C. Pinder, S.I. Hopkins, S.R. Wooller, S.K. Benstead-Hume, G. Pearl, F.M. Jeggo, P.A. Downs, J.A. (2019). Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability. Molecular cell, Vol.73 (2), pp. 212-223.e7.  show abstract

Benstead-Hume, G. Wooller, S.K. Downs, J.A. Pearl, F.M. (2019). Defining Signatures of Arm-Wise Copy Number Change and Their Associated Drivers in Kidney Cancers. , Vol.20 (22), p. E5762.  show abstract

Benstead-Hume, G. Chen, X. Hopkins, S.R. Lane, K.A. Downs, J.A. Pearl, F.M. (2019). Predicting synthetic lethal interactions using conserved patterns in protein interaction networks. Plos computational biology, Vol.15 (4), pp. e1006888-?.  show abstract

Jeggo, P.A. Downs, J.A. Gasser, S.M. (2017). Chromatin modifiers and remodellers in DNA repair and signalling. Philosophical transactions of the royal society of london. series b, biological sciences, Vol.372 (1731).

Hopkins, S.R. McGregor, G.A. Murray, J.M. Downs, J.A. Savic, V. (2016). Novel synthetic lethality screening method identifies TIP60-dependent radiation sensitivity in the absence of BAF180. , Vol.46, pp. 47-54.  show abstract

Myrianthopoulos, V. Gaboriaud-Kolar, N. Tallant, C. Hall, M.-. Grigoriou, S. Brownlee, P.M. Fedorov, O. Rogers, C. Heidenreich, D. Wanior, M. Drosos, N. Mexia, N. Savitsky, P. Bagratuni, T. Kastritis, E. Terpos, E. Filippakopoulos, P. Müller, S. Skaltsounis, A.-. Downs, J.A. Knapp, S. Mikros, E. (2016). Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis. , Vol.59 (19), pp. 8787-8803.  show abstract

Meisenberg, C. Ashour, M.E. El-Shafie, L. Liao, C. Hodgson, A. Pilborough, A. Khurram, S.A. Downs, J.A. Ward, S.E. El-Khamisy, S.F. (2016). Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. , , pp. gkw1026-gkw1026.  show abstract

Kakarougkas, A. Downs, J.A. Jeggo, P.A. (2015). The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks. Molecular & cellular oncology, Vol.2 (1), pp. e970072-e970072.

Alatwi, H.E. Downs, J.A. (2015). Removal of H2A Z by INO80 promotes homologous recombination. Embo reports, Vol.16 (8), pp. 986-994.  show abstract

Brownlee, P.M. Meisenberg, C. Downs, J.A. (2015). The SWI/SNF chromatin remodelling complex: Its role in maintaining genome stability and preventing tumourigenesis. Dna repair, Vol.32, pp. 127-133.

Niimi, A. Hopkins, S.R. Downs, J.A. Masutani, C. (2015). The BAH domain of BAF180 is required for PCNA ubiquitination. Mutation research/fundamental and molecular mechanisms of mutagenesis, Vol.779, pp. 16-23.

Schalbetter, S.A. Mansoubi, S. Chambers, A.L. Downs, J.A. Baxter, J. (2015). Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability. Proceedings of the national academy of sciences, Vol.112 (33).  show abstract

Brownlee, P.M. Chambers, A.L. Cloney, R. Bianchi, A. Downs, J.A. (2014). BAF180 promotes cohesion and prevents genome instability and aneuploidy. Cell reports, Vol.6 (6), pp. 973-981.  show abstract

Pal, M. Morgan, M. Phelps, S.E. Roe, S.M. Parry-Morris, S. Downs, J.A. Polier, S. Pearl, L.H. Prodromou, C. (2014). Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1. Structure, Vol.22 (6), pp. 805-818.

López-Perrote, A. Alatwi, H.E. Torreira, E. Ismail, A. Ayora, S. Downs, J.A. Llorca, O. (2014). Structure of Yin Yang 1 Oligomers That Cooperate with RuvBL1-RuvBL2 ATPases. Journal of biological chemistry, Vol.289 (33), pp. 22614-22629.

Kakarougkas, A. Ismail, A. Chambers, A.L. Riballo, E. Herbert, A.D. Künzel, J. Löbrich, M. Jeggo, P.A. Downs, J.A. (2014). Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin. Molecular cell, Vol.55 (5), pp. 723-732.  show abstract

Jeggo, P.A. Downs, J.A. (2014). Roles of chromatin remodellers in DNA double strand break repair. Experimental cell research, Vol.329 (1), pp. 69-77.

Chambers, A.L. Pearl, L.H. Oliver, A.W. Downs, J.A. (2013). The BAH domain of Rsc2 is a histone H3 binding domain. Nucleic acids research, Vol.41 (19), pp. 9168-9182.

Niimi, A. Chambers, A.L. Downs, J.A. Lehmann, A.R. (2012). A role for chromatin remodellers in replication of damaged DNA. Nucleic acids research, Vol.40 (15), pp. 7393-7403.

Brownlee, P.M. Chambers, A.L. Oliver, A.W. Downs, J.A. (2012). Cancer and the bromodomains of BAF180. Biochemical society transactions, Vol.40 (2), pp. 364-369.  show abstract

Chambers, A.L. Ormerod, G. Durley, S.C. Sing, T.L. Brown, G.W. Kent, N.A. Downs, J.A. (2012). The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres. Genes & development, Vol.26 (23), pp. 2590-2603.  show abstract

Chambers, A.L. Downs, J.A. (2012). The RSC and INO80 Chromatin-Remodeling Complexes in DNA Double-Strand Break Repair. , , pp. 229-261.

Foster, E.R. Downs, J.A. (2009). Methylation of H3 K4 and K79 is not strictly dependent on H2B K123 ubiquitylation. Journal of cell biology, Vol.184 (5), pp. 631-638.  show abstract

Titman, C.M. Downs, J.A. Oliver, S.G. Carmichael, P.L. Scott, A.D. Griffin, J.L. (2009). A metabolomic and multivariate statistical process to assess the effects of genotoxins in Saccharomycescerevisiae. Molecular biosystems, Vol.5 (12), pp. 1913-1913.

Downs, J.A. (2008). Histone H3 K56 acetylation, chromatin assembly, and the DNA damage checkpoint. Dna repair, Vol.7 (12), pp. 2020-2024.

Chambers, A.L. Downs, J.A. (2007). The contribution of the budding yeast histone H2A C-terminal tail to DNA-damage responses. Biochemical society transactions, Vol.35 (6), pp. 1519-1524.  show abstract

Kent, N.A. Chambers, A.L. Downs, J.A. (2007). Dual Chromatin Remodeling Roles for RSC during DNA Double Strand Break Induction and Repair at the Yeast MAT Locus. Journal of biological chemistry, Vol.282 (38), pp. 27693-27701.

Downs, J.A. (2007). Chromatin structure and DNA double-strand break responses in cancer progression and therapy. Oncogene, Vol.26 (56), pp. 7765-7772.

Bilsland, E. Hult, M. Bell, S.D. Sunnerhagen, P. Downs, J.A. (2007). The Bre5/Ubp3 ubiquitin protease complex from budding yeast contributes to the cellular response to DNA damage. Dna repair, Vol.6 (10), pp. 1471-1484.

Downs, J.A. Nussenzweig, M.C. Nussenzweig, A. (2007). Chromatin dynamics and the preservation of genetic information. Nature, Vol.447 (7147), pp. 951-958.

Bilsland, E. Downs, J.A. (2005). Tails of histones in DNA double-strand break repair. Mutagenesis, Vol.20 (3), pp. 153-163.

Harvey, A.C. Jackson, S.P. Downs, J.A. (2005). Saccharomyces cerevisiae Histone H2A Ser122 Facilitates DNA Repair. Genetics, Vol.170 (2), pp. 543-553.  show abstract

Zaid, O. Downs, J.A. (2005). Histones as tumour suppressor genes. Cellular and molecular life sciences, Vol.62 (15), pp. 1653-1656.

WARDLEWORTH, B.N. DOWNS, J.A. (2005). Spotting new DNA damage-responsive chromatin-binding proteins. Biochemical journal, Vol.388 (1).  show abstract

Downs, J.A. Cote, J. (2005). Dynamics of Chromatin during the Repair of DNA Double-Strand Breaks. Cell cycle, Vol.4 (10), pp. 1373-1376.

Downs, J.A. Jackson, S.P. (2004). A means to a DNA end: the many roles of Ku. Nature reviews molecular cell biology, Vol.5 (5), pp. 367-378.

Downs, J.A. Allard, S. Jobin-Robitaille, O. Javaheri, A. Auger, A. Bouchard, N. Kron, S.J. Jackson, S.P. Côté, J. (2004). Binding of Chromatin-Modifying Activities to Phosphorylated Histone H2A at DNA Damage Sites. Molecular cell, Vol.16 (6), pp. 979-990.

Downs, J.A. Kosmidou, E. Morgan, A. Jackson, S.P. (2003). Suppression of Homologous Recombination by the Saccharomyces cerevisiae Linker Histone. Molecular cell, Vol.11 (6), pp. 1685-1692.

Buratowski, R.M. Downs, J. Buratowski, S. (2002). Interdependent Interactions between TFIIB, TATA Binding Protein, and DNA. Molecular and cellular biology, Vol.22 (24), pp. 8735-8743.  show abstract

Downs, J.A. Lowndes, N.F. Jackson, S.P. (2000). A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature, Vol.408 (6815), pp. 1001-1004.

Downs, J.A. Jackson, S.P. (1999). Involvement of DNA End-Binding Protein Ku in Ty Element Retrotransposition. Molecular and cellular biology, Vol.19 (9), pp. 6260-6268.  show abstract

Foster, E.R. Downs, J.A. Histone H2A phosphorylation in DNA double-strand break repair. Febs journal, Vol.272 (13), pp. 3231-3240.

Harvey, A.C. Downs, J.A. What functions do linker histones provide?. Molecular microbiology, Vol.53 (3), pp. 771-775.

Chambers, A.L. Brownlee, P.M. Durley, S.C. Beacham, T. Kent, N.A. Downs, J.A. The Two Different Isoforms of the RSC Chromatin Remodeling Complex Play Distinct Roles in DNA Damage Responses. Plos one, Vol.7 (2), pp. e32016-e32016.

Somaiah, N. Yarnold, J. Anbalagan, S. Harrington, K. Downs, J. Wilkins, A. McBay, D. TP53 MODULATES RADIOTHERAPY FRACTION SIZE SENSITIVITY IN NORMAL AND MALIGNANT CELLS. Scientific reports, .

Wilkins, A. Fontana, E. Nyamundanda, G. Ragulan, C. Patil, Y. Mansfield, D. Kingston, J. Errington-Mais, F. Bottomley, D. von Loga, K. Bye, H. Carter, P. Tinkler-Hundal, E. Noshirwani, A. Downs, J. Dillon, M. Demaria, S. Sebag-Montefiore, D. Harrington, K. West, N. Melcher, A. Sadanandam, A. Differential and longitudinal immune gene patterns associated with reprogrammed microenvironment and viral mimicry in response to neoadjuvant radiotherapy in rectal cancer. J immunother cancer, Vol.9 (3).  show abstract

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